Off-topic cut damn this is interesting.
The blueprint of what can be accomplished with artificial molecular switches and machines is already available to us, thanks to biology.
(1,2) As to how we might attain the same level of exquisite control over molecular motion and function such that they could be harnessed in performing useful work, now that is the real question/challenge.
(3) What seems evident to me is that a well-orchestrated symphony of molecular interactions is required to translate molecular-level motion, which is usually induced on the sub-nanometer level into effects that can be measured and used on the micro and macro levels. For this goal to be attained—based on biological examples—alignment, order, directionality, tracks, signaling, communication, compartmentalization, amplification, fuel, regeneration, replication, waste management, temporal and spatial control, and feedback loops (the list goes on and on) are required. We have merely scratched the surface, and much more needs to be achieved before we reach the level of competence/sophistication required to overcome the obstacles in our paths toward engineering
useful artificial machines, i.e., molecular systems that transduce or interconvert nonequilibrium free energy without dissipating it (solely) as heat. The prize when and if—as we do not have the time scale that was available for biology—the end of the tunnel is reached will be revolutionary, reconfiguring every aspect of life and heralding a nanotechnological revolution.
(4?6) This transformation is the goal that has been, and is, fueling practitioners in the field, and stimulating the progress, development, and inroads that were made of late.
(7?11) Pushing things further will require a multidisciplinary approach and the implementation of ideas, concepts, and insights from other fields—biological machines after all did not develop only through chemistry.
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